Scientific Publications

The scientific staff of GeneNews™ have had numerous abstracts and articles published related to their work. The following is a selection of some of these publications.

The Sentinel Principle™

Liew, CC, Ma, J, Tang, HC, Zheng, R, Dempsey, AA. The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool. J Lab Clin Med 2006; 147:126-132. [abstract]

Cancer

Marshall KW, Chao S, Nossova N, et al. Stratification of colorectal cancer probability using six genes from whole blood. [Abstract] Proceedings of the 99th Annual Meeting of the American Association for Cancer Research; 2008 Apr 12-16; San Diego, CA. Philadelphia (PA): American Association for Cancer Research (AACR); 2008. Abstract no. LB-214.

Han M, Liew CT, Zhang HW et al. Novel, Blood-based Five-Gene Panel Biomarker Set for the Detection of Colorectal Cancer. Clin Cancer Res. 2008; 14:455-60.

Osman I, Bajorin DF, Sun TT, Zhong H, Douglas D, Scattergood J, Zheng R, Han M, Marshall KW, Liew CC. Novel Blood Biomarkers of Human Urinary Bladder Cancer Clin Cancer Res 2006;12(11):3374-3380.

Han M, Liew CT, Zhang HW, Yip KT, Song ZY, Li HM, Geng XP, Zhu LX, Marshall KW, Liew CC. Novel Blood Biomarker Panel Detects Human Colorectal Cancer Poster at American Society of Clinical Oncology (ASCO) Meeting, June 2-6, 2006.

Nam RK, Marshall KW, Zheng R, Zhang HW, Narod SA, Liew CC. Blood-based Biomarkers Identify Aggressive Prostate Cancer at Biopsy Poster at American Society of Clinical Oncology (ASCO) Meeting, June 2-6, 2006.

Osman, I, Bajorin, DF, Sun, TT, Mikhail, M, Zhong, H, Zheng, R, Han, M, Marshall, KW, Liew, CC. Gene Expression Profiling in Blood Cells Reveals Novel Biomarkers of Human Urinary Bladder Cancer. Poster at 2005 American Society of Clinical Oncology (ASCO) Meeting, May 13-17, 2005

Arthritis

Marshall, KW, Waddell, DD. Nonoperative management of osteoarthritis of the knee. McGraw-Hill Companies. 2000.

Zhang, H, Liew, CC, Marshall, KW. Microarray analysis reveals the involvement of beta-2 microglobulin (B2M) in human osteoarthritis. Osteoarthritis and Cartilage. 2002; 10:950-960

Zhang, HW, Marshall, KW, Tang, H, Hwang, DM, Lee, M, Liew, CC. Profiling genes expressed in human fetal cartilage using 13,155 expressed sequence tags. Osteoarthritis and Cartilage. 2003;11:309-319.

Yager, TD, Dempsey, AA, Tang, H, Stamatiou, D, Chao, S, Marshall, KW and Liew, CC. First Comprehensive Mapping of Cartilage Transcripts to the Human Genome. Genomics. 2004; 84:524-535.

Marshall, KW, Zhang, H, Yager, TD, Nossova, N, Dempsey, A, Zheng, R, Han, M, Tang, H, Chao, S, Liew, CC. Blood-Based Biomarkers for Detecting Mild Osteoarthritis in the Human Knee. Osteoarthritis and Cartilage 2005; 13: 861-871.

Cardiovascular

Hwang, DM, Dempsey, AA, Wang, RX, Rezvani, M, Barrans, JD, Dai, KS, Wang, HY, Ma, H, Cuckerman, E, Liu, YQ, Gu, JR, Zhang, JH, Tsui, SKW, Waye, M, Fung, KP, Lee, CY, Liew CC. A Genome-Based Resource for Molecular Cardiovascular Medicine. Circulation 1997;96:4146-4203

Ma, J, Liew, CC. Gene profiling identifies secreted protein transcripts from peripheral blood cells in coronary artery disease. JMCC. 2003;35:993-998

Gibbons,GH, Liew, CC, Goodarzi, MO, Rotter, JI, Hsueh, WA, Siragy, HM, Pratt, R, Dzau, VJ. Genetic Markers: Progress and Potential for Cardiovascular Disease. Circulation. 2004; 109 (25 Suppl 1):IV47-IV58

Liew, CC, Dzau, VJ. Molecular Genetics and Genomics of Heart Failure. Nature Reviews Genetics. 2004: 5: 811-825.

Liew, CC, Dzau, VJ. Human genome project and cardiovascular disease genes. In ed: Chien K. Molecular Basis of Cardiovascular Disease: A Companion to Braunwald's Heart Disease. Second Edition. WB Saunders. Philadelphia, PA. 2004

Liew, CC. Expressed Genome Molecular Signatures of Heart Failure Clinical Chemistry and Laboratory Medicine. 2005: 43: 462-469.

Central Nervous System Disorders

Glatt, SJ, Everall, IP, Kremen, WS, Corbeil, J, Sasik, R, Khanlou, N, Han, M, Liew, CC, Tsuang, MT. Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia. PNAS, 2005; 102:15533-15538.

Tsuang, MT, Nossova, N, Yager,T, Tsuang, MM, Guo, SC, Shyu, KG, Glatt, SJ and Liew, CC. Assessing the Validity of Blood-Based Gene Expression Profiles for the Classification of Schizophrenia and Bipolar Disorder: A preliminary Report. J Med Genet B Neuropsychiatr Genet. 2005;133B:1-5.