Breast cancer is the second leading cause of cancer death in U.S. women, exceeded only by lung cancer. The American Cancer Society estimates that approximately 232,670 new cases of invasive breast cancer will be diagnosed in women, and approximately 40,000 women will die from the disease, in 2014. Like with most cancers, early identification of high risk patients and intervention are the keys to improved clinical decision making. Most breast cancer cases are not due to genetic inheritance. Accordingly, it is important to take a “multi-view” approach to properly stratify women at the greatest risk.